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July 26, 2026Chiropractic & Manual TherapiesOpen Access

Spinal manipulation in acute low back pain patients is associated with reduced motor-unit firing variability without altering bilateral coordination: a single-motor-unit EMG study of the lumbar multifidus

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Authors

LLLise R. LotheTRTim J. L. RavenGSGunnar Sandbæk

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Overview

Single motor unit EMG study reveals altered motor unit firing variability post spinal manipulation in low back pain patients, suggesting implications for treatment.

Key Points

  • This study aims to investigate the effects of high velocity, low amplitude spinal manipulation on motor unit discharge characteristics in acute low back pain patients.
  • Fine-wire electrodes implanted in lumbar multifidus of 9 acute low back pain patients.
  • Motor unit discharge measured before and after spinal manipulation during various activities.
  • Analysis focused on discharge rate, interspike interval variability, and common drive coefficient.
  • Interspike interval variability reduced by 5.25 ms (95% CI 0.68–9.82; P = 0.025) after manipulation.
  • Common drive coefficient lower for bilateral motor unit pairs (−0.149; 95% CI −0.087 to −0.210; P < 0.0001).
  • Median discharge rate and gross activity duration remained unchanged post-manipulation.

Cite This Study

Lothe et al. (2026) studied this question.

synapsesocial.com/papers/6a65a890d3aea3239cd78df5https://doi.org/10.1186/s12998-026-00664-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ultrasound-assessed segmental lumbar motion and clinical outcomes following spinal manipulation: a randomized, controlled pilot study2026
  2. 2The impact of spinal manipulation on lumbar proprioception and its link to pain relief: a randomized controlled trial2025
  3. 3Systematic review on biomechanical effects of high-velocity, low amplitude spinal manipulation2025 · 6 citations
  4. 4One spinal manipulation session reduces local pain sensitivity but does not affect postural stability in individuals with chronic low back pain: a randomised, placebo-controlled trial2024 · 3 citations
  5. 5Safety and therapeutic outcomes of cervical high-velocity low-amplitude manipulation in clinical practice: a review2025 · 1 citations