What question did this study set out to answer?

The aim is to identify and functionally characterize a novel flavohemoglobin from Ensifer adhaerens and assess its impact on vitamin B12 production.

July 26, 2026Microbial Cell FactoriesOpen Access

Identification, functional characterization of a novel flavohemoglobin from Ensifer adhaerens and its application to enhancing vitamin B12 production

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Authors

JZJ F ZhuChina Mobile (China)SWS Q WangShandong University of Technology BLBo LiHarbin University of Science and Technology

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Implication

Randomized trial identifies and characterizes a flavohemoglobin enhancing vitamin B12 production in microbial platforms, suggesting important implications for fermentation processes.

Key Points

The aim is to identify and functionally characterize a novel flavohemoglobin from Ensifer adhaerens and assess its impact on vitamin B12 production.
Characterization of a novel flavohemoglobin from Ensifer adhaerens under oxygen-limiting conditions.
Heterologous expression of the flavohemoglobin in Escherichia coli.
Comparison of vitamin B12 production between wild-type and recombinant strains in a 50-L fermentation.
Overexpression of b12fla gene in E. adhaerens Casida A yielded 323 mg L−1 of vitamin B12 compared to 247 mg L−1 in wild-type.
Heterologous expression in E. coli increased cell growth and oxygen uptake rate by 12% and 65%, respectively.
Observed morphological changes in overexpressed strains indicated alterations in cell structure enhancing metabolic efficiency.

Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/6a65a8c9d3aea3239cd78f52 https://doi.org/10.1186/s12934-026-03073-z

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Implication

Randomized trial identifies and characterizes a flavohemoglobin enhancing vitamin B12 production in microbial platforms, suggesting important implications for fermentation processes.

Identification, functional characterization of a novel flavohemoglobin from Ensifer adhaerens and its application to enhancing vitamin B12 production

Discussion

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Implication

Key Points

Cite This Study

Identification, functional characterization of a novel flavohemoglobin from Ensifer adhaerens and its application to enhancing vitamin B12 production

Discussion

Member takes

Implication

Key Points

Cite This Study

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