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July 26, 2026Science Immunology

Dynamic regulation of lysine and arginine metabolism promotes immune evasion by limiting T cell function in cancer

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Authors

WYWeiwei YuRSRuya SunXLXiaoyang Lu

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Overview

Randomized trial investigates how tumors alter nutrient use to limit T cell activity, suggesting new therapeutic targets.

Key Points

  • The research aims to explore how tumors manipulate lysine and arginine metabolism to enhance immune evasion and support growth.
  • Identified the roles of SLC7A1 and SLC7A2 in arginine and lysine metabolism respectively.
  • Examined the effects of glutaconic acid on CD8 T cell function in the context of lysine catabolism reduction.
  • Studied pyruvate kinase M2 modifications by glutaconylation in tumor cells related to immune function.
  • Up-regulation of SLC7A1 increased arginine utilization, enhancing tumor growth.
  • Down-regulation of SLC7A2 led to decreased lysine catabolism and reduced immunostimulatory GC, impairing antitumor T cell function.
  • Glutaconylation of PKM2 reinforced dimerization, promoting metabolic changes that help evade the immune response.

Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/6a65a8c9d3aea3239cd78fc5https://doi.org/10.1126/sciimmunol.aeb7315
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Targeting Arginine Metabolism to Reverse Immune Paralysis in Cancer2026 · 1 citations
  2. 2Fine-tuning the lysine-arginine duet: a dietary approach to suppress tumor growth2026
  3. 3Metabolic reprogramming and immune evasion interaction in the tumor microenvironment promote tumor progression2026
  4. 4Glutamine sequestration promotes tumor growth and immune evasion through elevation of arginine methylation in hepatocellular carcinoma2026
  5. 5Lysosomal Rewiring Perpetuates Tumor Immune Evasion in Cancer2026