Demonstrates high yields and enantioselectivities in primary amine synthesis, suggesting effective catalysis.
The preparation of a series of enantioenriched α‐substituted primary amines using rhodium‐catalyzed asymmetric transfer hydrogenation of ortho‐ hydroxyaryl N─H imines is reported. The reaction proceeds under mild conditions using a low catalyst loading and ammonium formate as the hydrogen source, delivering the reduced compounds in high yields (up to 99%) and enantioselectivities (up to 99% ee).
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Liu et al. (2026) studied this question.
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