Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 26, 2026Systematic ReviewsOpen Access

Diagnostic accuracy of glycated albumin and fructosamine for detecting diabetes and prediabetes in adults: a systematic review and meta-analysis protocol

View Full Paper
Ask AI
Bookmark
Share

Key result

Systematic review protocol evaluates diagnostic accuracy of glycated albumin and fructosamine vs OGTT for diabetes.

Why the study?

Do glycated albumin and fructosamine accurately detect diabetes and prediabetes compared to the oral glucose tolerance test in adults?

Population

Adult populations being evaluated for diabetes and prediabetes

Comparison

Glycated albumin and fructosamine testing vs Oral glucose tolerance test (OGTT)

Design

Systematic_review

Authors

KFK. FernandoUniversity of KelaniyaDKDulani KottahachchiColombo North Teaching HospitalLPLochana PasanUniversity of Kelaniya

Discussion

Loading...

Member takes

Implication

This protocol outlines a systematic review and meta-analysis to evaluate the diagnostic accuracy of glycated albumin and fructosamine as alternatives to HbA1c for detecting diabetes and prediabetes.

Key Points

  • This review aims to assess the diagnostic accuracy of glycated albumin and fructosamine for detecting diabetes and prediabetes compared to the oral glucose tolerance test.
  • Systematic review and meta-analysis following PRISMA-DTA guidelines.
  • Databases searched include MEDLINE, Scopus, and Web of Science from inception to December 2025.
  • Studies evaluating glycated albumin or fructosamine against OGTT in adult populations will be included.
  • This review will provide pooled diagnostic accuracy measures for GA and FA.
  • Hierarchical summary receiver operating characteristic curves will be constructed to analyze results.
  • The findings will clarify the potential use of GA and FA as alternatives to HbA1c.

Study Design

Type

Systematic Review

Structured PICO

Do glycated albumin and fructosamine accurately detect diabetes and prediabetes compared to the oral glucose tolerance test in adults?

P
Population
Adult populations being evaluated for diabetes and prediabetes
E
Exposure
Glycated albumin (GA) and fructosamine (FA) testing
C
Comparator
Oral glucose tolerance test (OGTT)
O
Outcome
Diagnostic accuracy measures (pooled using a bivariate random-effects model and hierarchical summary receiver operating characteristic curves)surrogate

This protocol outlines a systematic review and meta-analysis to evaluate the diagnostic accuracy of glycated albumin and fructosamine as alternatives to HbA1c for detecting diabetes and prediabetes.

Cite This Study

Fernando et al. (2026) conducted a systematic review in Diabetes and prediabetes. Glycated albumin and fructosamine vs. Oral glucose tolerance test (OGTT) was evaluated on Diagnostic accuracy. This protocol outlines a planned systematic review and meta-analysis to evaluate the diagnostic accuracy of glycated albumin and fructosamine compared to OGTT for detecting diabetes in adults.

synapsesocial.com/papers/6a65a91fd3aea3239cd792a2https://doi.org/10.1186/s13643-026-03273-z
View Full Paper
Ask AI
Bookmark
Share