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July 26, 2026Interdisciplinary medicineOpen Access

Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

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Authors

LXLinfeng XiaoXCXiaowei ChangJZJun Zhang

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Overview

Review discusses mitochondria-targeted nanomedicines for cancer therapy, highlighting design strategies and challenges in clinical application.

Key Points

  • This review aims to summarize strategies for designing mitochondria-targeted nanomedicines and their mechanisms in cancer therapy.
  • Examined current design strategies for mitochondria-targeted nanoparticles.
  • Discussed antitumor mechanisms of these nanoparticles in cancer treatment.
  • Identified major challenges related to targeting efficiency and clinical translation.
  • Mitochondria-targeted nanoparticles enhance antitumor efficacy by disrupting redox balance and damaging mitochondrial structure.
  • These systems may reduce systemic toxicity and help overcome therapeutic resistance.
  • A comprehensive framework for the rational design of these nanoparticles is still lacking.

Cite This Study

Xiao et al. (2026) studied this question.

synapsesocial.com/papers/6a65a962d3aea3239cd7938chttps://doi.org/10.1002/inmd.70166
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