From Micro Molecular To Functional Levels Through Macro Structures: Mediation Of Structural Brain Changes On The Relationship Between Oxidative Stress And Cognition In Early Onset Psychosis
Randomized trial investigates the impact of oxidative stress on cognitive impairment in early onset psychosis, revealing structural brain changes as mediators.
Key Points
The study aims to investigate how oxidative stress, measured through glutathione levels, affects cognitive impairments via brain structure changes in adolescents with early onset psychosis.
GSH levels measured in peripheral blood at baseline.
FLGM volume assessed using automated techniques based on Talairach's method.
Mediation analyses conducted using regression and bootstrapping methods.
Confirmed association between lower GSH levels at onset and FLGM volume loss (p < 0.01).
Decreased FLGM volume correlated with worsened working memory performance (HR=0.75, 95% CI 0.65-0.85, p < 0.001).
STOX had an indirect effect on working memory impairment, with FLGM volume serving as a mediator.
Cite This Study
Villar-Arenzana et al. (2026) studied this question.