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July 26, 2026BMC Cardiovascular DisordersOpen Access

Higher TyG index is linked to ~216% greater odds of hypertension-diabetes comorbidity per SD.

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Why the study?

The study was conducted to investigate the associations between TyG-related indices and hypertension-diabetes comorbidity among middle-aged and older adults.

Are TyG-related indices associated with hypertension-diabetes comorbidity in middle-aged and older adults?

Population

2854 participants aged ≥ 45 years living in a suburban community

Comparison

Highest vs lowest quartile of TyG-related indices

Design

Suburban community-based cross-sectional study

Key result

Each 1-SD increment in the TyG index was significantly associated with increased odds of hypertension-diabetes comorbidity (OR 3.16; 95% CI 2.75-3.64; P<0.001).

Authors

FKFanlian KongYYY YJZJin Zhao

Discussion

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Member takes

Overview

TyG indices associate with hypertension-diabetes comorbidity; hypothesis-generating and should not yet change practice.

Key Points

  • This research aims to investigate the relationship between TyG-related indices and hypertension-diabetes comorbidity among middle-aged and older adults.
  • Included 2854 participants aged ≥ 45 years from a suburban community.
  • Utilized multivariable logistic regression to calculate odds ratios and confidence intervals.
  • Employed restricted cubic splines to assess dose-response relationships and ROC curves to evaluate discriminative performance.
  • 1-SD increment in TyG, TyG-BMI, and TyG-BRI resulted in adjusted ORs of 3.16 (95% CI 2.75–3.64), 1.39 (95% CI 1.15–1.66), and 1.37 (95% CI 1.22–1.54), respectively, all P < 0.001.
  • Highest quartile showed ORs of 30.99 (95% CI 16.97–62.97) for TyG, 6.42 (95% CI 4.20-10.14) for TyG-BMI, and 6.43 (95% CI 4.21–10.17) for TyG-BRI.
  • TyG showed the highest AUC of 0.786, indicating strong discriminative ability compared to TyG-BMI and TyG-BRI.

Study Design

Type

Cross-Sectional (n=2,854)

Structured PICO

Are TyG-related indices associated with hypertension-diabetes comorbidity in middle-aged and older adults?

P
Population
2,854 adults aged ≥ 45 years living in a suburban community evaluated for the association between TyG-related indices and hypertension-diabetes comorbidity.
E
Exposure
TyG-related indices (TyG, TyG-BMI, and TyG-BRI)
C
Comparator
Lowest quartile of TyG-related indices
O
Outcome
Hypertension-diabetes comorbidity (HTN-DM)

Main Result

Odds Ratio: 3.16 (95% CI 2.75–3.64)

p-value: p=<0.001

Cite This Study

Kong et al. (2026) conducted a cross-sectional in Hypertension-diabetes comorbidity (n=2,854). TyG-related indices (TyG, TyG-BMI, TyG-BRI) vs. Lower levels of TyG-related indices was evaluated on Hypertension-diabetes comorbidity (HTN-DM) (OR 3.16, 95% CI 2.75-3.64, p=<0.001). Each 1-SD increment in the TyG index was significantly associated with increased odds of hypertension-diabetes comorbidity (OR 3.16; 95% CI 2.75-3.64; P<0.001).

synapsesocial.com/papers/6a65aadfd3aea3239cd794c8https://doi.org/10.1186/s12872-026-06313-7
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