What question did this study set out to answer?

Summarize clinical pharmacokinetic and pharmacodynamic evidence to establish practical guidelines for individualized dosing of kinase inhibitors via therapeutic drug monitoring.

July 12, 2017Clinical Pharmacology & TherapeuticsOpen Access

Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology

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Authors

RVRemy B. VerheijenJohnson & Johnson (Netherlands)HYHuixin YuLeiden University JSJan H.M. SchellensAstraZeneca (United Kingdom)

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Implication

Clinical review reveals pharmacokinetic variability of kinase inhibitors in cancer patients, indicating the need for individualized therapeutic drug monitoring over standard fixed dosing.

Key Points

Summarize clinical pharmacokinetic and pharmacodynamic evidence to establish practical guidelines for individualized dosing of kinase inhibitors via therapeutic drug monitoring.
Reviewed clinical pharmacokinetic and pharmacodynamic literature evaluating exposure-response relationships for kinase inhibitors in oncology.
Synthesized findings from prospective therapeutic drug monitoring trials to outline implementation frameworks.
Demonstrated substantial pharmacokinetic exposure variability among cancer patients receiving standardized fixed doses of kinase inhibitors.
Formulated practical clinical recommendations linking drug exposure levels to individualized dose adjustment strategies.
Identified critical gaps and outlined prospective trial methodologies necessary for widespread implementation of therapeutic drug monitoring in oncology.

Cite This Study

Verheijen et al. (2017) studied this question.

synapsesocial.com/papers/6a66102ccd190748807e2b56 https://doi.org/10.1002/cpt.787

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Implication

Clinical review reveals pharmacokinetic variability of kinase inhibitors in cancer patients, indicating the need for individualized therapeutic drug monitoring over standard fixed dosing.

Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology

Discussion

Member takes

Implication

Key Points

Cite This Study

Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology

Discussion

Member takes

Implication

Key Points

Cite This Study

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