Single pulse electrical stimulation in white matter modulates iEEG visual responses in human early visual cortex

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Key Points

This research aims to understand how single pulse electrical stimulation affects neuronal processing of visual stimuli in the human brain.
Investigated two human subjects implanted with iEEG electrodes for clinical purposes.
Delivered single pulses to white matter tracts connected to visual cortex measurement electrodes.
Decomposed neurophysiological responses using finite impulse response modeling to analyze induced components.
Single pulses increased broadband power initially, followed by suppression, without modulating visual broadband responses.
Significant brain stimulation evoked potentials were noted, which amplified visual evoked potentials when stimulation occurred close to visual onset.

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Investigates electrical stimulation's effect on visual processing in humans, suggesting interactive modulation of inputs.

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Huang et al. (2026) studied this question.

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