Addendum: RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions

Q: What does this research mean for the field?

The RAF/MEK/extracellular signal-related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Brandon Hogstad; Marie‐Luise Berres; Rikhia Chakraborty; Jun Tang; Camille Bigenwald; Madhavika Serasinghe; Karen Phaik Har Lim; Howard Lin; Tsz‐Kwong Man; Romain Remark; Samantha Baxter; Veronika Kana; Stefan Jordan; Zoi Karoulia; Wing-Hong Kwan; Marylène Leboeuf; Elisa Brandt; Hélène Salmon; Kenneth McClain; Poulikos Poulikakos; Jerry E. Chipuk; Willem J. M. Mulder; Carl E. Allen; Miriam Mérad

doi:10.1084/jem.2016188107092026a

Key Points

The objective is to clarify the role of the RAF/MEK/ERK pathway in dendritic cell behavior within Langerhans cell histiocytosis lesions.
Examination of the RAF/MEK/extracellular signal–related kinase pathway
Assessment of dendritic cell migration
Review of figure duplication in results
Clarification of the duplication in the BRAFV600E + MEKi plot
Confirmation of dendritic cell trapping in LCH lesions
Highlighting the importance of accurate data representation

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Implication

Clarification on the RAF/MEK/ERK pathway's role in dendritic cell migration and LCH lesions indicating its importance.

Abstract

The authors wish to clarify that duplication of the "BRAFV600E + MEKi" plot in Fig. 3 B

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Cite This Study

Hogstad et al. (2026) studied this question.

synapsesocial.com/papers/6a67004840bca442e0d4a0d2 https://doi.org/10.1084/jem.2016188107092026a

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Addendum: RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions

Key Points

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Implication

Abstract

Discussion

Cite This Study

Addendum: RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions

Key Points

No abstract yet

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Implication

Abstract

Discussion

Cite This Study

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