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July 24, 2026The International Journal of Spine SurgeryOpen Access

Assessment of Bone Bridging of a Novel Wet-Field Regenerative Bone Adhesive for Lumbar Spine Fusion in an Ovine Model at 12, 26, and 52 Weeks

Kevin T. Foley Eric J. Woodard Jonathan R. Slotkin Ben Gadomski Caroline D. Woodard Michael C. Brown Brian Hess

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Key Points

This study aims to investigate the efficacy of TTCP-PS bone adhesive for lumbar fusion compared to a commercial graft substitute.
An ovine lumbar fusion model was used, involving 20 sheep and bilateral implantation of TTCP-PS and a control.
Implants were stabilized with a pedicle screw fixation system and assessed through X-ray and CT scans at 12, 26, and 52 weeks.
Histological findings were analyzed to evaluate bone fusion across time points.
TTCP-PS sites achieved 57% bone bridging at 26 weeks compared to 31% in the control group (p=0.001).
By 52 weeks, the mean percentage bone growth area for TTCP-PS was 52%, while the control was 45%.
TTCP-PS demonstrated superior safety and effectiveness as a bone graft substitute, promoting earlier bone formation.

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Implication

Evaluates TTCP-PS bone adhesive efficacy for lumbar fusion in sheep, suggesting improved outcomes.

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Cite This Study

Foley et al. (2026) studied this question.

synapsesocial.com/papers/6a67007840bca442e0d4a115 https://doi.org/10.14444/8924

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