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July 27, 2026Tissue Barriers

Irisin-treated microbiota restore blood–testis barrier integrity and spermatogenesis in chronically stressed rats

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Authors

IDItishree DubeyMYManisha YadavSKSapana Kushwaha

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Overview

Randomized trial investigates irisin's effect on sperm quality and gut microbiota, suggesting a new approach for male fertility issues.

Key Points

  • The study aims to evaluate the impact of irisin on restoring blood-testis barrier integrity and spermatogenesis in chronically stressed rats.
  • Randomized control trial with male Sprague-Dawley rats divided into four groups: Control, CUS, CUS + Control-FMT, CUS + Irisin-FMT.
  • Chronic unpredictable stress (CUS) model used with fecal microbiota transplantation (FMT) from irisin or vehicle-treated donors.
  • FMT administered intra-rectally for 2 weeks, with irisin given subcutaneously for 4 weeks.
  • Irisin-FMT group showed significant improvements in sperm quality and hormonal profiles (testosterone, LH, FSH).
  • Increased crypt length, goblet cells, and restoration of Johnsen’s index observed in the irisin-treated group.
  • Upregulation of blood-testis barrier proteins and suppression of inflammatory markers were reported.

Cite This Study

Dubey et al. (2026) studied this question.

synapsesocial.com/papers/6a67007840bca442e0d4a13dhttps://doi.org/10.1080/21688370.2026.2700679
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