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July 27, 2026ONCOLOGIEOpen Access

Ginsenoside Rg3 enhances antitumor effects of PD-1 mAb in lung adenocarcinoma by promoting T-cell mitophagy via TBC1D15

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Authors

ZKZhang KhYLYilong LiXQXiating Qian

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Overview

Randomized trial examines Rg3's effect in boosting anti-tumor immunity in lung cancer, suggesting promising adjuvant therapy.

Key Points

  • The study aims to determine if ginsenoside Rg3 can enhance the antitumor effects of anti-PD-1 therapy in lung adenocarcinoma by promoting T-cell mitophagy.
  • In vitro co-culture of tumor cells and cytotoxic T cells to assess antitumor efficacy.
  • Utilized techniques include flow cytometry, quantitative PCR, Western blotting, RNA sequencing, and a mouse tumor xenograft model.
  • Gene knockdown and overexpression approaches validated key molecular mediators.
  • Rg3 reduced A549 lung adenocarcinoma cell viability by 45.9% at 10 μmol/L (p<0.05).
  • Combination treatment increased CTL-mediated killing rates to 71.9%, compared to 50.7% for anti-PD-1 mAb alone and 48.2% for Rg3 alone (all p<0.05).
  • Upregulation of TBC1D15 in CTLs was linked to enhanced mitochondrial integrity and cytolytic activity following combined treatment.

Cite This Study

Kh et al. (2026) studied this question.

synapsesocial.com/papers/6a67009540bca442e0d4a6afhttps://doi.org/10.1515/oncologie-2026-0123
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