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July 27, 2026International ImmunologyOpen Access

Innate immune responses underlying local and systemic adverse reactions to mRNA-lipid nanoparticle vaccines

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Authors

TTTomohiro TakanoTMTakayuki MatsumuraYTYoshimasa Takahashi

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Overview

Review summarizes immune responses linked to adverse reactions in vaccine contexts, suggesting implications for design.

Key Points

  • The aim is to understand the innate inflammation processes leading to local and systemic adverse reactions to mRNA-LNP vaccines.
  • Reviewed recent evidence on inflammatory pathways and their relationship with adverse reactions.
  • Discussed the role of cytokine networks in amplifying systemic symptoms.
  • Considered interactions between innate immunity and adaptive immune responses.
  • IL-1 was identified as a major contributor to adverse reactions, alongside IL-6, TNF-α, and type I IFN.
  • Cytokine responses vary based on experimental models and vaccination context.
  • Altered innate responses linked to immune memory from booster doses complicate reactogenicity.

Cite This Study

Takano et al. (2026) studied this question.

synapsesocial.com/papers/6a6700af40bca442e0d4a91fhttps://doi.org/10.1093/intimm/dxag040
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