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July 27, 2026Behavioral and Brain FunctionsOpen Access

Bilateral cortical network disruptions in the rat caudal forelimb area after unilateral stroke

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Authors

CCCheng’an CaoDCDi ChenJGJin Gong

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Overview

Randomized trial investigates neural activity changes after stroke in rats, suggesting motor deficits arise from network disruptions.

Key Points

  • This research aims to assess how ischemic stroke affects neural dynamics in the caudal forelimb area and the mechanisms behind motor deficits.
  • Local field potentials recorded from ipsilateral and contralateral CFA in rats during a single-pellet retrieval task.
  • Analyses included spectral power assessments, aperiodic slope characterization, and cross-frequency coupling evaluation.
  • Pilot experiment involved sham-operated control for comparison and verification of measures.
  • Ischemic stroke led to significant bilateral disruptions in oscillatory dynamics across various frequency bands.
  • Altered excitation–inhibition balance observed through changes in the aperiodic 1/f slope.
  • Impaired interhemispheric coordination indicated by reorganization of cross-frequency coupling between hemispheres.

Cite This Study

Cao et al. (2026) studied this question.

synapsesocial.com/papers/6a6700af40bca442e0d4a94fhttps://doi.org/10.1186/s12993-026-00355-9
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