Elevated TyG-BMI conferred a stronger association with cumulative cardiometabolic multimorbidity incidence than reduced eGDR-BMI (HR > 1.5, p < 0.01).
Cohort
Do BMI-adjusted insulin resistance indices (eGDR and TyG) predict cardiometabolic multimorbidity risk in adults with hypertension and sarcopenia?
Elevated TyG-BMI and reduced eGDR-BMI are significantly associated with increased risk of cardiometabolic multimorbidity in adults with hypertension and sarcopenia, suggesting utility for risk stratification.
Effect estimate: HR > 1.5
p-value: p=< 0.01
Background Cardiometabolic multimorbidity (CMM) and obesity are growing global public health burdens. The obesity paradox, however, obscures how insulin resistance (IR) shapes CMM risk in individuals with coexisting hypertension and sarcopenia, a question that remains unresolved.Methods Two body mass index (BMI)-adjusted IR indices – the estimated glucose disposal rate (eGDR) and the triglyceride glucose index (TyG) – were assessed in the China Health and Retirement Longitudinal Study (CHARLS) cohort over a median follow-up of 8 years.Results Cox regression revealed that eGDR–BMI and HDL-C were inversely associated with CMM risk, while TyG–BMI and platelet count were positively associated (all p 1.5, p < 0.01). Restricted cubic spline modeling confirmed nonlinear dose–response relationships (p nonlinear < 0.05), yielding cutoff values of 7.5 for eGDR–BMI and 196.6 for TyG–BMI. The TyG–BMI-based model achieved superior predictive performance among all models evaluated (AUC = 0.702).Conclusions These findings establish clinically meaningful associations and threshold values of eGDR–BMI and TyG–BMI with CMM risk, highlighting the value of weight management and routine lipid and platelet monitoring in middle-aged and older adults with coexisting hypertension and sarcopenia.
Zou et al. (Sat,) conducted a cohort in Hypertension with sarcopenia. Elevated TyG-BMI vs. Reduced eGDR-BMI was evaluated on Cumulative cardiometabolic multimorbidity (CMM) incidence (HR > 1.5, p=< 0.01). Elevated TyG-BMI conferred a stronger association with cumulative cardiometabolic multimorbidity incidence than reduced eGDR-BMI (HR > 1.5, p < 0.01).