Key result
Addressing HF from acute or chronic injury and insufficient remodeling remains critical for population health.
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Insufficient post-MI remodeling drives most HF; leaves open targeted healing modulators.
H eart failure remains a critical target to improve the health of the US population.It is a major cause of morbidity and mortality in the United States. 1 Heart failure is a result of acute or chronic injury followed by healing and remodeling that are insufficient to maintain or restore function.Myocardial infarction (MI) is the major cause of heart dysfunction, but other more chronic injuries, such as those caused by hypertension or genetic defects have many similarities.
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Richard M. Mortensen (2012) conducted a review in Heart failure. Heart failure resulting from acute or chronic injury and insufficient remodeling remains a critical target to improve population health.
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