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July 28, 2026JCEM Case ReportsOpen Access

Bilateral giant myelolipomas in a female patient with untreated 21-hydroxylase deficiency

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Authors

AWAnn-Christin WelpMAMatthias K. AuerLTLea Tschaidse

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Overview

Case report illustrates the impact of untreated 21-hydroxylase deficiency leading to myelolipomas, suggesting the need for hormonal management.

Key Points

  • To explore the development of bilateral giant myelolipomas in a patient with untreated 21-hydroxylase deficiency.
  • Case report of a 59-year-old female with untreated classic congenital adrenal hyperplasia for over 30 years.
  • Bilateral adrenalectomy was performed, followed by glucocorticoid and mineralocorticoid replacement therapy.
  • Postoperative improvement in hyperandrogenemia and associated symptoms, such as hirsutism and amenorrhea.
  • Bilateral giant myelolipomas measured 24.5 cm × 20.5 cm × 9.7 cm on the left and 14.5 cm × 11.6 cm × 6.5 cm on the right.

Cite This Study

Welp et al. (2026) studied this question.

synapsesocial.com/papers/6a6850fb2845b684d16f0202https://doi.org/10.1210/jcemcr/luag176
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