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July 28, 2026Clinics and PracticeOpen Access

Gambling Disorder as a Behaviorally Driven Systemic Medical Condition: From Reward Circuitry to Multi-System Morbidity

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Authors

MBMartina BallerioPMPiercarlo MinorettiEEEnzo Emanuele

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Overview

Narrative review uncovers the somatic dimensions of gambling disorder, suggesting systemic involvement and new treatment avenues.

Key Points

  • This review aims to explore the somatic dimensions and systemic implications of gambling disorder (GD).
  • Narrative review synthesizing cross-sectional and prospective evidence on somatic aspects of GD.
  • Investigated four somatic axes: cardiovascular, metabolic, sleep-related, and neurological dimensions.
  • Proposed candidate biological systems linking GD to multi-system physiology.
  • Identified cardiovascular issues like hypertension and stroke in GD.
  • Noted increased metabolic disorders such as obesity and type 2 diabetes.
  • Highlighted potential therapeutic role of glucagon-like peptide-1 receptor agonists in managing GD.

Cite This Study

Ballerio et al. (2026) studied this question.

synapsesocial.com/papers/6a685d012845b684d16f0716https://doi.org/10.3390/clinpract16080137
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between endocrine and neuropsychological endophenotypes and gambling disorder severity2024 · 6 citations
  2. 2Gambling disorder in the context of couple relationships: a systematic review2026
  3. 3Pharmacological management of gambling disorder: an update of the literature2024 · 11 citations
  4. 4Gambling disorder in a university hospital setting: a retrospective analysis of patient characteristics2026
  5. 5Combating Gaming Disorder in 2024: A Survival Manual2024