Randomized trial reveals peroxidasin's role in fibrosis and kidney function decline in IgA nephropathy, suggesting its therapeutic potential.
Key Points
This research aimed to characterize peroxidasin expression in kidney tissues of patients with IgA nephropathy and its association with fibrosis and kidney function.
Characterized PXDN expression using immunofluorescence in kidney biopsies from patients with IgA nephropathy.
Assessed correlations between PXDN levels, collagen deposition, and kidney function (eGFR).
PXDN expression was significantly higher in the fibrotic interstitium and correlated with collagen III deposition.
Patients with impaired kidney function (eGFR < 60 ml/min/1.73 m²) showed increased PXDN expression in glomeruli.
Glomerular PXDN levels inversely correlated with eGFR, indicating a link between PXDN and declining kidney function.