Key result
Depressive disorders affect 20% of patients with coronary heart disease and are theorized to increase mortality through increased thrombus formation and autonomic dysregulation.
Depression in patients with coronary heart disease worsens the disease course through mechanisms including autonomic dysregulation and increased thrombosis.
Depression may worsen CHD outcomes via autonomic and endothelial effects; leaves open causal mechanisms for prospective trials.
The prevalence of depressive disorders at the population level is from 2,5 to 10% among patients with coronary heart disease - 20%. The presence of depressive disorders in patients with coronary artery disease leads to hypersympathicotonia decrease vagal activity, endothelial dysfunction and blood coagulation system, weighing down the disease. The most significant theories of pathophysiological mechanism of increased mortality in patients with cardiovascular disease in combination with mood disorders are increased thrombus formation and disturbance of the autonomic regulation of heart rhythm.
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Нонка et al. (2014) conducted a review in Coronary heart disease. Depressive disorders was evaluated. Depressive disorders affect 20% of patients with coronary heart disease and are theorized to increase mortality through increased thrombus formation and autonomic dysregulation.
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