Key result
Higher isoflavone intake linked to ~13% lower incident CHD risk.
Why the study?
Does higher isoflavone intake reduce the risk of incident coronary heart disease in US men and women?
Population
210,700 US men and women who were free of cardiovascular disease and cancer at baseline.
Comparison
Higher isoflavone intake vs Lower isoflavone intake
Design
Cohort
Follow-up
4,826,122 person-years
Authors
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Higher intake of isoflavones, particularly tofu, is associated with a moderately lower risk of developing coronary heart disease, especially in younger women and postmenopausal women not using hormones.
Cohort (n=210,700)
Yes
Does higher isoflavone intake reduce the risk of incident coronary heart disease in US men and women?
Hazard Ratio: 0.87 (95% CI 0.81–0.94)
p-value: p=0.008
Higher intake of isoflavones, particularly tofu, is associated with a moderately lower risk of developing coronary heart disease, especially in younger women and postmenopausal women not using hormones.
Ma et al. (2020) conducted a cohort in Coronary Heart Disease (n=210,700). Isoflavone intake vs. Lowest quintile of intake was evaluated on Incident CHD (nonfatal myocardial infarction and CHD deaths) (HR 0.87, 95% CI 0.81-0.94, p=0.008). Higher isoflavone intake was associated with a lower risk of incident coronary heart disease compared to the lowest quintile of intake (HR 0.87; 95% CI 0.81-0.94; P=0.008).
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