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July 29, 2026Fluids and Barriers of the CNSOpen Access

Blood-brain barrier and blood-tumoral barrier formation in glioblastoma: endothelial cells and glioblastoma stem cells at the immune-brain crossroad

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Authors

MRMaria RositoRLRuth LyckBEBritta Engelhardt

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Overview

Review examines glioblastoma's tumor microenvironment and crosstalk between glioma stem cells and endothelial cells.

Key Points

  • This review aims to explore the interactions between glioma stem cells and the blood-brain barrier in glioblastoma and how these interactions affect tumor progression.
  • Reviewed experimental strategies including 2D and 3D cell cultures, organoids, and in vivo models.
  • Evaluated strengths and limitations of various approaches to understand intercellular interactions.
  • Discussed the influence of the perivascular niche on glioma stem cell behavior.
  • Identified key modes of crosstalk that sustain the proliferation and resistance of glioma stem cells.
  • Highlighted the complexity of the tumor microenvironment in contributing to glioblastoma progression.
  • Emphasized the need for well-characterized experimental models to inform targeted therapies.

Cite This Study

Rosito et al. (2026) studied this question.

synapsesocial.com/papers/6a69a24dc8da07d9defa59efhttps://doi.org/10.1186/s12987-026-00850-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Glioblastoma Stem Cells and Tumour Microenvironment: Interactions Across Hypoxia, Vasculature and Immune Modulation2026 · 4 citations
  2. 2Modeling blood–brain barrier–glioblastoma interactions: implications for chemoresistance and therapeutic targeting2026 · 1 citations
  3. 3Targeting Glioblastoma Stem Cells: Therapeutic Strategies and Clinical Perspectives2026 · 5 citations
  4. 4Targeting the Tumor Micro-environmental in Glioblastoma: Barriers, Pathways, and Experimental Strategies2026
  5. 5Blood-tumor barrier in focus - investigation of glioblastoma-induced effects on the blood-brain barrier2024 · 7 citations