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July 29, 2026The Egyptian Journal of Neurology Psychiatry and NeurosurgeryOpen Access

Optical coherence tomography: a tool for predicting subclinical neurodegeneration in RRMS

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Authors

LDLamiaa I. DakerSSSherin Hassan SadekMAM Ahmed

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Overview

Randomized trial examines OCT's role in detecting neurodegeneration in RRMS, suggesting its utility for early diagnosis.

Key Points

  • To evaluate the reliability of optical coherence tomography (OCT) in detecting subtle disease progression in RRMS patients.
  • Included 25 Egyptian patients with RRMS and 25 matched healthy controls for comparison.
  • Conducted neurological examinations, cognitive function assessments with PASAT, brain MRI, and OCT evaluations at baseline and after 9 months.
  • Analyzed correlations between OCT parameters, cognitive scores, relapse rates, and MRI findings.
  • MS patients had significantly lower PASAT scores and OCT parameters compared to controls.
  • History of optic neuritis correlated with reduced RNFL and GCC thickness and increased FLV and GLV.
  • Significant positive correlations were found between RNFL change rate, PASAT score, and annual relapse rate.

Cite This Study

Daker et al. (2026) studied this question.

synapsesocial.com/papers/6a69a25ec8da07d9defa5bf8https://doi.org/10.1186/s41983-026-01206-0
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