Mechanochemical Diastereoselective Substrate-Directed Synthesis of Pyrrole-Isoxazolidines via 1,3-Dipolar Cycloaddition of Maleimides with Nitrones

selectivity, and on the basis of this, empirical guidelines are presented for predicting the diastereoselectivity as a function of substituents in this cycloaddition. Furthermore, this mechanochemical approach provided a protocol with short reaction times and simple processing, eliminating the need for column chromatography purification. Scaling up to one product and detailed green metrics to all products indicated that this mechanochemical approach is a greener route in relation to the traditional solvent methods.