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July 29, 2026mBioOpen Access

Francisella -primed T cells shift toward glycolysis during control of intramacrophage bacterial growth

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Authors

LMLara MitterederKEKaren L. Elkins

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Overview

Randomized trial shows that metabolic activity in T cells correlates with protection against Francisella in mice, suggesting new vaccine approaches.

Key Points

  • To investigate how metabolic shifts in T cells influence their ability to control Francisella bacterial growth within macrophages.
  • Used an in vitro co-culture assay to assess the control of bacterial replication by T cells.
  • Profiled metabolic activities of lymphocytes and macrophages from mice vaccinated with F. tularensis Live Vaccine Strain.
  • Conducted gene expression analyses on splenic T cells from co-cultures.
  • LVS-primed lymphocytes displayed increased glycolysis compared to naïve cells.
  • LVS-primed T cells showed a significant reduction in respiratory capacity, indicating an effector T cell state.
  • Metabolic genes were upregulated in LVS-primed T cells and detectable in peripheral blood lymphocytes.

Cite This Study

Mittereder et al. (2026) studied this question.

synapsesocial.com/papers/6a69a26dc8da07d9defa5cd1https://doi.org/10.1128/mbio.01133-26
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