Demonstrates efficient alkylation of chlorocyclobutenones using pro-aromatic intermediates, suggesting a new synthetic approach.
-dichlorocyclobutenones, contrasting β-selective radical addition in Giese-type addition. This base- and oxidant-free method provides efficient access to highly functionalized 4-alkylated α-chlorocyclobutenones. Furthermore, aldehyde-derived pro-aromatic 4-alkyl-1,4-dihydropyrides served as C-radical precursors, enabling the synthesis of 4-alkylated α-chlorocyclobutenones under similar reaction conditions.
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Mondal et al. (2026) studied this question.
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