What question did this study set out to answer?

To investigate how progressive resistance training affects irisin concentrations and cognitive function in healthy older adults aged over 65.

July 29, 2026The Journal of Strength and Conditioning Research

The Effect of Progressive Resistance Training on Irisin and Cognition in Healthy Older Adults

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Authors

JNJames E. NewmanUniversity of the Sunshine Coast IKI. KingUniversity of the Sunshine Coast NFNicole B. FlemmingUniversity of the Sunshine Coast

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Implication

Randomized trial examines the impact of resistance training on cognition and irisin levels in older adults, suggesting exercise influences brain health.

Key Points

To investigate how progressive resistance training affects irisin concentrations and cognitive function in healthy older adults aged over 65.
Single-arm exercise trial involving 30 healthy adults aged >65 years over 12 weeks.
Participants underwent 12 weeks of progressive resistance training, 3 times per week, at 80% 1-repetition maximum.
Measurements of body composition, cognition, and circulating irisin were assessed pre- and post-training, with additional irisin samples taken post-exercise.
Peak irisin concentrations increased significantly after a single resistance exercise session (1.8 ± 3.6 ng·ml −1, p < 0.001).
Verbal fluency improved after training (1.0 ± 1.7 points, p = 0.007).
Memory change correlated with pre-training basal and post-training peak irisin levels (r < 0.423, p < 0.040).

Cite This Study

Newman et al. (2026) studied this question.

synapsesocial.com/papers/6a69a28ac8da07d9defa60b2 https://doi.org/10.1519/jsc.0000000000005477

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Implication

Randomized trial examines the impact of resistance training on cognition and irisin levels in older adults, suggesting exercise influences brain health.

The Effect of Progressive Resistance Training on Irisin and Cognition in Healthy Older Adults

Discussion

Member takes

Implication

Key Points

Cite This Study

The Effect of Progressive Resistance Training on Irisin and Cognition in Healthy Older Adults

Discussion

Member takes

Implication

Key Points

Cite This Study

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