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July 26, 2026Journal of Medicinal Chemistry

Discovery of 1 H -Indole-3-Propionamide Derivatives as Potent, Selective and Orally Available Na V 1.7 Inhibitors for Pain Treatment

Kai Chen Xi He Gaoang Wang Wu Hh Xiangying Liu Lin Wang Yizhi Wu Xue Liu Longying Shen Yaling Gong Li‐Ping Bai Baolian WANG Xiandao Pan Tingjun Hou Xi Zhou Xiaojian Wang

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Key Points

The objective is to discover novel compounds that inhibit Na V 1.7 for effective pain management.
Developed 1 H-Indole-3-Propionamide derivatives as potential Na V 1.7 inhibitors.
Tested analgesic efficacy across various murine models of pain.
Derivatives showed potent analgesic effects in models of acute, chronic inflammatory, and neuropathic pain.
Identified lead compound with promising oral bioavailability.

Abstract

displayed robust analgesic efficacy across various murine models of acute, chronic inflammatory, and neuropathic pain. The findings of the study highlight a highly promising, orally available lead compound for pain treatment.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a69a28ac8da07d9defa60f9 https://doi.org/10.1021/acs.jmedchem.6c00882

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