Randomized trial investigates plumbagin's synergistic effect with antibiotics on biofilm in Staphylococcus aureus, suggesting new treatment options.
Key Points
This research aims to evaluate the effectiveness of plumbagin combined with ceftazidime and cefazolin in inhibiting biofilm formation by Staphylococcus aureus.
Investigated the synergistic effects of plumbagin, ceftazidime, and cefazolin against Staphylococcus aureus biofilm.
Measured the reduction in biofilm formation and bacterial cell counts (CFU/mL) with various combinations.
Utilized scanning electron microscopy and exopolysaccharide quantification to analyze treatment effects.
Inhibition of over 80% of Staphylococcus aureus biofilm formation compared to individual compounds.
Reduction of bacterial cells by over 3 log10 CFU/mL with combined treatments.
Significant decrease in exopolysaccharide production to 28.29 μg glucose/mg biofilm, compared to 65 μg glucose/mg biofilm in untreated cells.