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July 29, 2026Discover OncologyOpen Access

Ferroptosis-related lncRNA signature predicts prognosis and immune microenvironment remodeling in laryngeal squamous cell carcinoma

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Authors

HXHaibo XuMXMeiling XuHWHuijie Weng

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Overview

Randomized trial identifies ferroptosis-related lncRNA signatures predicting outcomes in LSCC, suggesting a targeted role for immunotherapy.

Key Points

  • This study aims to investigate the role of ferroptosis-related lncRNAs in the immune microenvironment of laryngeal squamous cell carcinoma and their prognostic value.
  • Analyzed TCGA transcriptomic and clinical data through co-expression analysis to identify ferroptosis-related lncRNAs.
  • Developed a prognostic signature using LASSO Cox regression and assessed survival performance via Kaplan-Meier analysis and ROC curves.
  • Evaluated tumor immune infiltration using ssGSEA and ESTIMATE algorithms, analyzing immune checkpoint expression relationships.
  • The four-lncRNA signature stratified LSCC patients into distinct survival groups and served as an independent overall survival predictor.
  • High-risk tumors showed reduced infiltration of activated CD8 + T cells, NK cells, and dendritic cells, with more MDSCs.
  • The risk score correlated negatively with PD-L1 expression and was linked to reduced adaptive immune signatures, indicating an immune-cold phenotype.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2a3c8da07d9defa6445https://doi.org/10.1007/s12672-026-05647-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of a novel ferroptosis-related lncRNA signature for prognostic prediction in hepatocellular carcinoma2026
  2. 2A ferroptosis-related signature predicts the clinical diagnosis and prognosis, and associates with the immune microenvironment of lung cancer2024 · 4 citations
  3. 3Integrated analysis of a competing endogenous RNA network reveals a ferroptosis-related 6-lncRNA prognostic signature in clear cell renal cell carcinoma2024 · 4 citations
  4. 4A signature of four ferroptosis-related genes in laryngeal squamous cell carcinoma2024 · 1 citations
  5. 5Construction of a prognostic prediction model for diffuse large B-cell lymphoma patients based on ferroptosis-related LncRNAs2026