Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 29, 2026Journal of Molecular PathologyOpen Access

High Expression of PgRMC1 Correlates with Poor Neoadjuvant Chemotherapy Response and Alters Chemosensitivity in Breast Cancer Cells

View Full Paper
Ask AI
Bookmark
Share

Authors

MTManami TadaTCTomohiro ChibaYIYoshiharu Ishizaka

Discussion

Loading...

Member takes

Overview

Randomized trial examines PgRMC1 expression and its role in neoadjuvant chemotherapy response in breast cancer, suggesting new biomarkers.

Key Points

  • This study aims to explore the correlation between PgRMC1 expression and neoadjuvant chemotherapy response in breast cancer patients.
  • Evaluated PgRMC1 expression in breast tissues via immunohistochemistry.
  • Measured mRNA levels of PgRMC1 and other biomarkers in 112 patients using qPCR.
  • Assessed pretreatment biopsy intrinsic subtypes and pathological response in a 44-patient cohort post-NAC.
  • PgRMC1 was overexpressed in breast cancer tissue versus normal tissue.
  • Patients with poor pathological response had higher PgRMC1 levels compared to those with a good response.
  • In vitro overexpression of PgRMC1 resulted in decreased chemosensitivity and altered marker expression.

Cite This Study

Tada et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2aec8da07d9defa668ehttps://doi.org/10.3390/jmp7030027
View Full Paper
Ask AI
Bookmark
Share