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July 29, 2026CureusOpen Access

Analgesic Effects of Low Dose Ketamine in Patients Undergoing Spine Fusion Surgery

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Prospective observational cohort study evaluates low-dose ketamine for pain management in spine surgery, suggesting enhanced postoperative recovery.

This research aims to evaluate the analgesic effects of low-dose ketamine in patients undergoing spine fusion surgery.
Prospective observational cohort study involving 44 patients
Patients divided into two groups: one receiving low-dose ketamine infusion and the other regular analgesics
Pain measured using Visual Analog Scale (VAS) over 48 hours
Ketamine group showed significantly lower VAS pain scores at 4, 6, 12, and 18 hours postoperatively (p<0.05)
Lower cumulative opioid use in the ketamine group with a mean difference of -16.00 (CI: -19.68 to -12.32, P<0.0001)
Patients reported higher satisfaction and shorter hospital stays in the ketamine group (mean: 4.45 days vs. 5.77 days)

Singh et al. (2026) studied this question.

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Prospective observational cohort study evaluates low-dose ketamine for pain management in spine surgery, suggesting enhanced postoperative recovery.