Demonstrates a metal-free carbonyl desaturation method for synthesizing flavones, suggesting a safer approach for pharmaceuticals.
-Michael addition. This protocol is a metal-free approach to carbonyl desaturation with nontoxic DMSO as both the solvent and oxidant, which is especially beneficial for the synthesis of pharmaceutical compounds. Mechanistic studies suggest that the transformation proceeds via a radical pathway.
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Mao et al. (2026) studied this question.
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