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This study investigates coagulation and fibrinolysis parameters across healthy and complicated pregnancies.

Coagulation and Fibrinolysis in Normal Pregnancy and Complicated Pregnancy

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Retrospective analysis compares coagulation and fibrinolysis in normal pregnancies with GDM and PE, highlighting differences in outcomes.

This study investigates coagulation and fibrinolysis parameters across healthy and complicated pregnancies.
Retrospective study involving 293 pregnant women undergoing prenatal check-ups.
Comparison of coagulation and fibrinolysis parameters across groups: non-pregnant, healthy pregnancies, GDM, and PE.
Measurement of prothrombin time, activated partial thromboplastin time, fibrinogen, and various fibrinolysis markers.
In normal pregnancy, PT, APTT, and TT were significantly shortened with elevated FIB, FDP, D-dimer, PAI-1, and tPA compared to non-pregnant controls.
GDM showed higher PAI-1 and tPA but lower PIC, while PE exhibited prolonged APTT and complex changes in both coagulation and fibrinolysis.
Overweight and obesity were linked to increased PAI-1 in healthy women at delivery and those with GDM.

Su et al. (2026) studied this question.

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