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July 29, 2026Journal of Medical VirologyOpen Access

SARS‐CoV‐2 mRNA Vaccination Induces Neutralizing Antibodies and Type I IFN Changes in People Living With HIV

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Authors

FFFederica FrascaLMLuca MaddaloniADAlessandra D’Auria

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Overview

Randomized trial shows changes in neutralizing antibodies and interferon levels in people living with HIV, suggesting effective vaccination response.

Key Points

  • This study aims to evaluate the changes in neutralizing antibodies and type I interferon following mRNA vaccination in people living with HIV.
  • Examined 75 people living with HIV and 28 healthy donors.
  • Measured anti-Spike antibodies and type I interferon levels at multiple time points post-vaccination.
  • Analyzed correlations with demographic and immunological factors including CD4 T cell count.
  • PLWH exhibited an increase in anti-S IgG levels comparable to healthy donors (p < 0.001).
  • Induction of anti-S neutralizing antibodies observed (p < 0.014 for T2 vs. T3).
  • CD4 T cell count positively correlated with IFN-I response (p < 0.05).

Cite This Study

Frasca et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2c7c8da07d9defa6a46https://doi.org/10.1002/jmv.71067
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