What question did this study set out to answer?

This study aims to compare oncological outcomes of salvage mastectomy versus alternative treatments for ipsilateral breast tumor recurrence after initial breast-conserving therapy.

July 29, 2026The OncologistOpen Access

Salvage Treatment Strategies for Ipsilateral Breast Tumor Recurrence after Breast-Conserving Therapy: a Real-World Study

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This study aims to compare oncological outcomes of salvage mastectomy versus alternative treatments for ipsilateral breast tumor recurrence after initial breast-conserving therapy.
Retrospective analysis of data from the SEER database on female patients with ipsilateral breast tumor recurrence after breast-conserving surgery and radiotherapy.
Outcomes assessed included overall survival, breast cancer-specific survival, and cumulative incidence of second ipsilateral breast tumor recurrence using propensity score matching.
Patients divided into groups receiving salvage mastectomy, repeat breast-conserving surgery alone, repeat breast-conserving surgery with re-irradiation, and mastectomy with re-irradiation.
Participants included 4,651 patients with comparable overall and breast cancer-specific survival across treatment groups post-matching.
The cumulative incidence of 10-year second ipsilateral breast tumor recurrence was significantly higher in the repeat breast-conserving surgery alone group (5.04%) compared to mastectomy (0.36%, P=0.002).
Re-irradiation did not show significant improvement in outcomes for patients with triple-negative tumors.

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Implication

Real-world analysis evaluates survival outcomes for treatment options after breast cancer recurrence, informing future choices.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2d4c8da07d9defa6bcc https://doi.org/10.1093/oncolo/oyag274

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Salvage Treatment Strategies for Ipsilateral Breast Tumor Recurrence after Breast-Conserving Therapy: a Real-World Study

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Cite This Study

Salvage Treatment Strategies for Ipsilateral Breast Tumor Recurrence after Breast-Conserving Therapy: a Real-World Study

Key Points

Discussion

Implication

Cite This Study

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