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This research focuses on developing and optimizing topical film-forming sprays for the sustained release of etoricoxib.

Polymeric topical film-forming sprays for sustained release of etoricoxib: formulation, optimization, and characterization

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Randomized trial demonstrates the effectiveness of etoricoxib film-forming sprays in chronic pain management, suggesting improved patient compliance.

This research focuses on developing and optimizing topical film-forming sprays for the sustained release of etoricoxib.
Formulation using a quality by design (QbD) approach with Eudragit S-100 and PEG 400.
Evaluation of viscosity and drying time using response surface methodology (RSM) quadratic model.
In vitro drug release studies to assess sustained release behavior.
Eudragit S-100 significantly influenced viscosity (p<0.05).
PEG 400 had a dominant effect on drying time (p<0.05).
In vitro release showed 30.68% for Batch 1 and 35.26% for Batch 2 over 8 hours.

Chinwala et al. (2026) studied this question.

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View Full Paper

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Authors

Randomized trial demonstrates the effectiveness of etoricoxib film-forming sprays in chronic pain management, suggesting improved patient compliance.

This research focuses on developing and optimizing topical film-forming sprays for the sustained release of etoricoxib.
Formulation using a quality by design (QbD) approach with Eudragit S-100 and PEG 400.
Evaluation of viscosity and drying time using response surface methodology (RSM) quadratic model.
In vitro drug release studies to assess sustained release behavior.
Eudragit S-100 significantly influenced viscosity (p<0.05).
PEG 400 had a dominant effect on drying time (p<0.05).
In vitro release showed 30.68% for Batch 1 and 35.26% for Batch 2 over 8 hours.

Chinwala et al. (2026) studied this question.

View Full Paper

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