Demonstrates engineered nonheme Fe enzymes enable enantioselective transformations, suggesting a new approach for synthesizing amino acids.
exhibited similar kinetic isotope effects for both 1,5- and 1,6-HAT pathways, suggesting that enzyme engineering controls regio- and enantioselectivity but does not alter the intrinsic transition-state properties of the HAT event. Together, these results further established engineered nonheme Fe enzymes as an excellent platform for the development of stereoselective, synthetically useful non-native biocatalytic transformations.
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Liu et al. (2026) studied this question.
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