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July 29, 2026JAMA Network OpenOpen Access

Intraarterial Dexamethasone for Pain Relief After Uterine Fibroid Embolization

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Authors

KBKenneth BrileyUniversity of MiamiRRReddy RkUniversity of MiamiACArais CavadaUniversity of Miami

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Implication

Randomized trial shows intraarterial dexamethasone reduces postprocedural pain in women undergoing UFE, suggesting a simple pain management strategy.

Key Points

  • To assess whether intraarterial dexamethasone can effectively reduce postprocedural pain following uterine fibroid embolization.
  • Conducted as a double-blind, placebo-controlled randomized clinical trial.
  • Involved women aged 20 to 50 undergoing uterine fibroid embolization.
  • Participants received either 10 mg intraarterial dexamethasone or saline placebo during the procedure.
  • Dexamethasone group reported significantly lower mean pain scores immediately after the procedure (4.0 vs 6.1, P = .04).
  • Pain scores remained lower in the dexamethasone group through 96 hours (2.4 vs 4.5, P = .02).
  • No significant differences in uterine volume reduction between groups at 3 months (37.4% vs 29.6%, P = .30).

Cite This Study

Briley et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2e2c8da07d9defa6e45https://doi.org/10.1001/jamanetworkopen.2026.25004
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Maine Womenʼs Health Study1994 · 201 citations
  2. 2Perioperative Single Dose Systemic Dexamethasone for Postoperative Pain2011 · 777 citations
  3. 3World Medical Association Declaration of Helsinki2013 · 31,105 citations