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July 29, 2026TrialsOpen Access

Development of a database for investigating characteristics and quality of published clinical trials in chronic obstructive pulmonary disease: design, implementation, and application

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Authors

YZYu ZhangYZYanfei ZhaoPZP Zhang

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Overview

Database establishes structured access to COPD trials, highlighting improved data integration and quality assessment.

Key Points

  • The aim is to develop a curated clinical trial database for chronic obstructive pulmonary disease (COPD) research.
  • Conducted a systematic literature search for clinical trials published before June 30, 2023.
  • Extracted trial data using CONSORT standards and assessed bias with ROB 2.0.
  • Merged English and Chinese literature results to establish the database.
  • Identified 36,127 English RCTs and 142,670 Chinese RCTs; 2261 primary trial reports included after addressing duplication.
  • Most trials focused on drug treatment (48.1%) and pulmonary rehabilitation (26.8%).
  • Demonstrated the effectiveness of a dual-track retrieval strategy that surpassed single search methods.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2e2c8da07d9defa6e65https://doi.org/10.1186/s13063-026-09923-w
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