Finds hand plaques help diagnose autoimmune disorders in SIADH, suggesting critical implications for treatment.
In apparently idiopathic syndrome of inappropriate antidiuretic hormone secretion (SIADH), chilblain‐like hand plaques may reveal autoimmune connective tissue disease. Skin examination, biopsy, and serology can uncover discoid lupus erythematosus with Sjögren's syndrome overlap. Serum sodium improvement after skin treatment requires caution because spontaneous stabilization cannot be excluded.
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Watanabe et al. (2026) studied this question.
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