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July 29, 2026Workplace Health & Safety

Workplace Safety Considerations in Post-Exposure HIV Prophylaxis: A Case Report of Atypical Hypersensitivity in a Healthcare Worker

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Authors

RGRiya GoelEmory UniversityLALaura AspeyEmory UniversityGLGhiara Alexandra Lugo-Diaz

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Implication

Case report observes atypical hypersensitivity reactions in a healthcare worker undergoing HIV PEP, highlighting significant safety considerations.

Key Points

  • This report aims to highlight hypersensitivity reactions associated with post-exposure prophylaxis in healthcare settings. It focuses on a case that illustrates specific allergy risks and their implications for occupational health.
  • Described a case involving a 58-year-old female physician experiencing hypersensitivity reactions while on occupational PEP.
  • Documented sequential regimen substitution with darunavir due to initial drug reactions.
  • Highlighted the importance of allergy risk stratification in urgent PEP protocols.
  • The physician experienced acute vulvovaginal hypersensitivity within one hour of starting bictegravir/emtricitabine/tenofovir alafenamide.
  • Substitution with darunavir led to drug-induced hypersensitivity syndrome, presenting a severe reaction risk.
  • The patient completed the prophylactic course without seroconversion to HIV or hepatitis B virus.

Cite This Study

Goel et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2f1c8da07d9defa70fdhttps://doi.org/10.1177/21650799261470385
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