Representation of melanoma depth staging with limited central section sampling: a retrospective simulation study

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Key Points

This study aims to determine if a central section of melanoma specimens accurately reflects Breslow thickness and ulceration compared to full sectioning.
Retrospective analysis of histological slides from 78 invasive melanomas in 76 patients.
Tumor thickness and ulceration were measured across all tissue sections.
Comparison made between the measurements from the most central section and the overall specimen.
Median difference in maximum depth measurement was below 0.2 mm (IQR 0.02, p < 0.001).
Ulceration was detectable in the central section in all cases where present (11.5%).
T-stage remained unchanged in 93.6% of cases, only 5 cases showed higher stages after full workup.

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Retrospective study assesses central section accuracy for staging melanoma in patients, indicating potential for improved treatment efficacy.

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Pustelnik et al. (2026) studied this question.

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