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July 29, 2026Animal BioscienceOpen Access

Genome-wide identification of long non-coding RNAs in pigs and their roles in muscle development

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Authors

HLHang LiuHWHao WangLWLigang Wang

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Overview

Randomized trial identifies lncRNAs influencing muscle development in pigs, suggesting regulatory mechanisms.

Key Points

  • The study aimed to create a detailed lncRNA atlas for pigs and examine their roles in muscle development.
  • Analyzed 8,871 RNA-seq datasets to identify porcine lncRNAs.
  • Characterized transcriptional features, tissue specificity, and eQTL relationships.
  • Integrated multi-omics approaches including single-cell RNA-seq and Hi-C analyses.
  • Identified 50,203 porcine lncRNA genes with significant tissue specificity.
  • Highlighted PRANCR as a key regulator of postnatal muscle growth in Laiwu pigs.
  • Proposed an enhancer-lncRNA mechanism impacting SOX8 binding and PRANCR expression.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2f1c8da07d9defa7169https://doi.org/10.5713/ab.260444
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