What question did this study set out to answer?

This review aims to assess the effectiveness and safety of opioid-free and opioid-sparing pain control strategies during surgical anesthesia.

July 29, 2026CureusOpen Access

Opioid-Free and Opioid-Sparing Pain Control in Surgical Anesthesia: A Scoping Review of Multimodal Analgesia, Regional Techniques, and Recovery Outcomes

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Scoping review evaluates opioid-free and opioid-sparing strategies for pain control, indicating potential benefits in outcomes.

This review aims to assess the effectiveness and safety of opioid-free and opioid-sparing pain control strategies during surgical anesthesia.
Conducted a scoping review of literature published from January 2018 to May 2026.
Included and narratively mapped 46 articles across various analgesic strategies and recovery outcomes.
Focused on pharmacologic strategies, regional techniques, and enhanced recovery after surgery pathways.
Opioid-free and opioid-sparing approaches may reduce perioperative opioid exposure and related adverse effects.
Strongest benefits observed when non-opioid drugs, regional techniques, and ERAS principles are used together.
Outcomes remain heterogeneous, suggesting the need for individualized strategies rather than a one-size-fits-all approach.

Shukla et al. (2026) studied this question.

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