Key result
Extracellular mitochondrial DNA was detected in the synovial fluid of 70% of patients with rheumatoid arthritis compared to 0% of non-arthritic controls.
Why the study?
Are extracellular mtDNA and 8-oxodG levels elevated in the synovial fluid and plasma of patients with rheumatoid arthritis compared to controls?
Case-Control (n=106)
No
Are extracellular mtDNA and 8-oxodG levels elevated in the synovial fluid and plasma of patients with rheumatoid arthritis compared to controls?
Absolute Event Rate: 70% vs 0%
p-value: p=<0.0001
Extracellular mtDNA and oxidized DNA are significantly elevated in the synovial fluid and plasma of patients with rheumatoid arthritis, suggesting a potential role in joint inflammation.
No takes yet. Share an insight, caveat, or question.
May implicate extracellular mtDNA in RA synovitis; hypothesis-generating and should not change practice.
Hajizadeh et al. (2003) conducted a case-control in Rheumatoid arthritis (n=106). Rheumatoid arthritis vs. Non-arthritic controls and healthy volunteers was evaluated on Presence of extracellular PCR-amplifiable mitochondrial DNA in synovial fluid (p=<0.0001). Extracellular mitochondrial DNA was detected in the synovial fluid of 70% of patients with rheumatoid arthritis compared to 0% of non-arthritic controls.
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