Key result
Older age significantly attenuated muscle sympathetic nerve activity increases during head-down rotation compared to young subjects (12% vs 85%, P<0.01).
Why the study?
Does aging attenuate the cardiovascular and sympathetic responses to otolithic stimulation in humans?
Population
22 subjects, comprising 11 young (mean age 26 +/- 1 years) and 11 older (mean age 64 +/- 1 years) individuals.
Comparison
Otolithic stimulation via head-down rotation in… vs Young subjects and head rotation in the lateral…
Design
Cross-sectional
Authors
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Blunted sympathetic responses to otolith stimulation in older adults may heighten orthostatic intolerance risk; leaves open vestibular-targeted interventions.
Cross-Sectional (n=22)
Does aging attenuate the cardiovascular and sympathetic responses to otolithic stimulation in humans?
Absolute Event Rate: 12% vs 85%
p-value: p=<0.01
Aging significantly attenuates the vestibulosympathetic reflex, which may contribute to the increased prevalence of orthostatic hypotension in older adults.
Ray et al. (2002) reported a cross-sectional. Older age vs. Young age was evaluated on Increase in muscle sympathetic nerve activity (MSNA) during head-down rotation (p=<0.01). Older age significantly attenuated muscle sympathetic nerve activity increases during head-down rotation compared to young subjects (12% vs 85%, P<0.01).
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