Synthèse de deux nouveaux acides amines phénoliques comportant un cycle 1,2,4‐oxadiazole

Synthesis of two phenolic amino acids containing the 1,2,4‐oxadiazole ring The synthesis of α‐amino‐β [3‐( p ‐hydroxyphenyl)‐1,2,4, oxadiazol‐5‐yl]propionic acid (9) and its β‐amino isomer (10) (see scheme 3 ) is reported. By condensation of p ‐benzyloxy‐benzamide oxime and N‐benzyloxycarbonyl asparagine the derivatives 4 and 5 (see scheme 1 ) are obtained leading after deprotection to 9 and 10 . The synthesis of N‐carboxyanhydride of 4 (6) and its corresponding amino acid (7) and amide (8) is also described.